Mathematical modeling, simulation, and data analysis for advancing early clinical detection of sepsis in critically ill patients


This project aims at combining current research in critical care medicine and concepts and methods of scientific computing to achieve urgently needed progress in the following areas:

  • Reliable early detection of sepsis as a systemic inflammatory host response to infection (by e.g. bacteria, fungi or parasites)
  • Development of efficient procedures for direct clinical application of obtained results
  • Development of new therapeutic approaches with particular regard to immunosuppression as part of the dynamic inflammatory process

On the one hand, methods for clinical data processing and for analysis of documented clinical expertise will be used. On the other hand, the complex system of the inflammatory process is analyzed, mathematically modeled and simulated in view of the given problem. Available medical knowledge as well as understanding gained from existing and prospectively collected data contribute to the modeling effort. On their part, resulting models and simulations thereof enable the examination of hypotheses derived from medical expertise and data analyses.

Since January 2016 the project receives funding from Klaus Tschira Stiftung and is entitled SCIDATOS (Scientific Computing for the Improved Diagnosis and Therapy of Sepsis).

Link to project website.

Name and contact of project responsible(s):

Prof. Dr. med. Manfred Thiel (University Medical Centre Mannheim)
Prof. Dr. Dr. h.c. mult. Hans Georg Bock (Interdisciplinary Center for Scientific Computing, Heidelberg University)

Involved scientists and partners

OA Dr. med. Thomas Kischning (University Medical Centre Mannheim)
Dr. med. Verena Schneider-Lindner, PhD (University Medical Centre Mannheim)
Dr. Holger A. Lindner (University Medical Centre Mannheim)
Prof. Dr. sc. hum. habil. Christel Weiß (Abteilung für Medizinische Statistik, Biomathematik und Informationsverarbeitung)
Prof. Dr. Dr. h.c. mult. Willi Jäger (Interdisciplinary Center for Scientific Computing, Heidelberg University)
Prof. Dr. Ekaterina A. Kostina (Interdisciplinary Center for Scientific Computing, Heidelberg University)
Prof. Dr. Anna Marciniak-Czochra (Interdisciplinary Center for Scientific Computing, Heidelberg University)
Dr. Maria Neuss-Radu (University of Erlangen-Nürnberg and Interdisciplinary Center for Scientific Computing Heidelberg)
Prof. Dr. Stefan Riezler (Department of Computational Linguistics, Heidelberg University)
Prof. Dr. Michael Gertz (Institute of Computer Science, Heidelberg University)